diff --git a/apis/python/setup.cfg b/apis/python/setup.cfg
index b5df47753e..596d4346ca 100644
--- a/apis/python/setup.cfg
+++ b/apis/python/setup.cfg
@@ -35,7 +35,7 @@ install_requires =
     pyarrow
     scanpy
     scipy
-    tiledb>=0.17.4
+    tiledb>=0.17.5
 python_requires = >3.7
 
 [options.extras_require]
diff --git a/apis/python/setup.py b/apis/python/setup.py
index de5e0c55f8..2c48766eeb 100644
--- a/apis/python/setup.py
+++ b/apis/python/setup.py
@@ -115,7 +115,7 @@ def run(self):
             "pyarrow",
             "scanpy",
             "scipy",
-            "tiledb>=0.17.0",
+            "tiledb>=0.17.5",
         ],
         python_requires=">=3.7",
         ext_modules=get_ext_modules(),